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Protein Kinase CK2

Cylene Articles:

Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells. Cancer Lett. 2012;.
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CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy. Mol Can Ther. 2012;
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Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs. Bioorg Med Chem Lett. 2012;22(1):45-8.
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Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer. Biochem Biophys Res Commun 2011;415(1):163-7.
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Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer. Mol Cell Biochem 2011;356(1-2):37-43.
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Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry 2011;50(39):8478-88.
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Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties. Biorg Med Chem Lett. 2011;21(6):1687-91.
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Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer. J Med Chem 2011 54(2):635-54
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CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy. Cancer Res 2010;70(24):10288-98.
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Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia. Blood 2010;116(15): 2724-31.
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CK2 in disease Pathways: Protein kinase CK2 in human diseases.Curr Med Chem 2008;15(19):1870-86.
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CK2 as a Cancer Target: Emergence of protein kinase CK2 as a key target in cancer therapy.Biofactors 2010;36(3):187-95.
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CK2 addiction: Addiction to protein kinase CK2: a common denominator of diverse cancer cells?Biochim Biophys Acta 2010;1804(3):499-504.
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CK2 Biology: CK2: A key player in cancer biology.Cell Mol Life Sci 2009 66(11-12) 1858-67
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CK2 Kinase Review: Protein kinase CK2: An ugly duckling in the kinome pond.Cell Mol Life Sci 66 (11-12) 1795-92009.
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RNA Polymerase I and p53 Activation

Cylene Articles:

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth.Cancer Res 2011; 71(4):1418-30.
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The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol 2010;50:131-56.
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Pol I-Mdm2-p53 pathway: Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway.Oncogene 2010;29(30):4253-60.
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p53 activation in the clinic: Translating p53 into the clinic.Nat Rev Clin Oncol 2010.
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p53 activation therapies: Awakening guardian angels: drugging the p53 pathway.Nat Rev Cancer 2009;9(12):862-73.
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Pol I-Mdm2-p53 pathway: Signaling to p53: ribosomal proteins find their way.Cancer Cell 2009;16(5):369-77.
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p53 in hematological malignancies: The significance of TP53 in lymphoid malignancies: mutation prevalence, regulation, prognostic impact and potential as a therapeutic target.Br J Haematol 2009;146(3):257-69.
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Pim Kinases

Cylene Articles:

Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med Chem Lett. 2012;21(22):6687-92.
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7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011;21(22):6687-92.
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Pim Kinases in cancer: For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer 2010;11(1):23-34.
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Pim 1 and C-Myc: Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma.Oncogene 2010;29(17):2477-87.
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Pim 1 and C-Myc: Pim kinase-dependent inhibition of c-Myc degradation.Oncogene 2008, 27 35) 4809-19.
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Pim Kinases in cancer: Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal.Eur J Cancer 2008;44(15):2144-51.
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Pim and Akt overlap: The survival kinases Akt and Pim as potential pharmacological targets.J Clin Invest 2005;115(10):2618-24.
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